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Inhibition of TNKS1 expression can suppress cell proliferation in glioma xenografts.HE staining to observe cell morphology in each group (A); immunohistochemistry to detect <t>Ki-67</t> values in cells from each group (B), with an asterisk (*) indicating a significant difference compared to the TNKS1-siRNA NC group, P < 0.05. Scale bar = 50 μm.
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Inhibition of TNKS1 expression can suppress cell proliferation in glioma xenografts.HE staining to observe cell morphology in each group (A); immunohistochemistry to detect <t>Ki-67</t> values in cells from each group (B), with an asterisk (*) indicating a significant difference compared to the TNKS1-siRNA NC group, P < 0.05. Scale bar = 50 μm.
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Inhibition of TNKS1 expression can suppress cell proliferation in glioma xenografts.HE staining to observe cell morphology in each group (A); immunohistochemistry to detect <t>Ki-67</t> values in cells from each group (B), with an asterisk (*) indicating a significant difference compared to the TNKS1-siRNA NC group, P < 0.05. Scale bar = 50 μm.
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Inhibition of TNKS1 expression can suppress cell proliferation in glioma xenografts.HE staining to observe cell morphology in each group (A); immunohistochemistry to detect <t>Ki-67</t> values in cells from each group (B), with an asterisk (*) indicating a significant difference compared to the TNKS1-siRNA NC group, P < 0.05. Scale bar = 50 μm.
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Inhibition of TNKS1 expression can suppress cell proliferation in glioma xenografts.HE staining to observe cell morphology in each group (A); immunohistochemistry to detect Ki-67 values in cells from each group (B), with an asterisk (*) indicating a significant difference compared to the TNKS1-siRNA NC group, P < 0.05. Scale bar = 50 μm.

Journal: IBRO Neuroscience Reports

Article Title: TNKS1 mediates the PTEN-PI3K/AKT pathway to regulate glycolysis and proliferation in gliomas

doi: 10.1016/j.ibneur.2026.01.007

Figure Lengend Snippet: Inhibition of TNKS1 expression can suppress cell proliferation in glioma xenografts.HE staining to observe cell morphology in each group (A); immunohistochemistry to detect Ki-67 values in cells from each group (B), with an asterisk (*) indicating a significant difference compared to the TNKS1-siRNA NC group, P < 0.05. Scale bar = 50 μm.

Article Snippet: The primary antibody used was rabbit anti-Ki67 antibody (HA721115, 1:200, HUABIO, USA), which was incubated overnight at 4°C.

Techniques: Inhibition, Expressing, Staining, Immunohistochemistry